Progress in Personalised Computational Models of Physiology for Clinical Application

In this talk I will examine some of the challenges of translation of computational physiological models to applications in clinical medicine and in personal health management. I will include discussion of the whole pipeline, from data collection through to model personalisation and results interpretation. I am convinced that, to maximise impact, our models need to represent the physiology of the patient in a range of situations as they live their lives (their physiological envelope). I will review the history, challenges and progress in perhaps the most successful translational application of computational haemodynamics, in coronary application, including fractional flow reserve computations and beyond.