In this talk I will examine some of the challenges of translation of computational physiological models to applications in clinical medicine and in personal health management. I will include discussion of the whole pipeline, from data collection through to model personalisation and results interpretation. I am convinced that, to maximise impact, our models need to represent the physiology of the patient in a range of situations as they live their lives (their physiological envelope). I will review the history, challenges and progress in perhaps the most successful translational application of computational haemodynamics, in coronary application, including fractional flow reserve computations and beyond.


D. Rodney Hose

Department of Infection, Immunity and Cardiovascular Disease and Insigneo Institute for In Silico Medicine, University of Sheffield, United Kingdom

Date and time

Monday, 05 October 2020, 2:00-3:30 PM (CEST)


  • Online via ZOOM
  • Register HERE to attend the Seminar